Scientists funded by the National Institutes of Health have discovered a potential strategy for developing treatments to stem the disease process in Alzheimer’s disease. It’s based on unclogging removal of toxic debris that accumulates in patients’ brains, by blocking activity of a little-known regulator protein called CD33

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  1. Genetic Switch Involved in Depression Researchers have discovered a gene regulator that is over-expressed in brains of both depressed patients and rats that show depression-like behaviors. Boosting expression of the regulator, Gata1, decreased expression of genes that code for the connections between neurons in rats’ thinking and feeling circuitry, as well as the number of such synapses....
  2. Medicare Card: Gene Linked to Alzheimer’s Disease Plays Key Role in Cell Survival Scientists have discovered that a gene linked to Alzheimer’s disease may play a beneficial role in cell survival by enabling neurons to clear away toxic proteins. A study funded by the National Institute on Aging (NIA), part of the National Institutes of Health, shows the presenilin 1 (PS1) gene is essential to the function of […]...
  3. Protein linked to Parkinson’s disease may regulate fat metabolism National Institutes of Health researchers have found that Parkin, an important protein linked with some cases of early-onset Parkinson’s disease, regulates how cells in our bodies take up and process dietary fats....
  4. Medicare – Targeting the Blood-Brain Barrier, May Delay Progression of Alzheimer’s Disease Researchers may be one step closer to slowing the onset and progression of Alzheimer's disease. An animal study supported by the National Institute of Environmental Health Sciences (NIEHS), ...
  5. Level of tumor protein indicates chances cancer will spread Researchers at the National Institutes of Health and the University of Hong Kong have discovered that high levels of a particular protein in cancer cells are a reliable indicator that a cancer will spread....
  6. Lower blood pressure goal benefits African-Americans with chronic kidney disease, protein in the urine On average, a lower blood pressure goal was no better than the standard blood pressure goal at slowing progression of kidney disease among African-Americans who had chronic kidney disease resulting from high blood pressure, according to results of the African-American Study of Kidney Disease and Hypertension (AASK), the largest and longest study of chronic kidney […]...
  7. Medicare Card, Therapy with bone marrow-derived stem cells does not improve short-term recovery after heart attack Medicare Card, Therapy with bone marrow-derived stem cells does not improve short-term recovery after heart attack...
  8. Study ties blood protein to Alzheimer’s brain abnormalities Scientists are seeking ways to detect the earliest stages of Alzheimer’s disease, since harmful changes may be taking place in the brain years before symptoms appear. Now, researchers report that a blood test detecting a specific protein in blood samples from cognitively normal older people may reflect the levels of beta-amyloid protein in the brain […]...
  9. New model of ALS is based on human cells from autopsied tissue By isolating cells from patients’ spinal tissue within a few days after death, researchers funded by the National Institutes of Health have developed a new model of the paralyzing disease amyotrophic lateral sclerosis (ALS). They found that during the disease, cells called astrocytes become toxic to nerve cells — a result previously found in animal […]...
  10. Key step identified in Legionnaire’s disease infection process NIH researchers have uncovered a key step in the biochemical sequence the bacterium which causes Legionnaire’s disease uses to reproduce inside the cells it infects....
  11. Key step identified in Legionnaire’s disease infection process NIH researchers have uncovered a key step in the biochemical sequence the bacterium which causes Legionnaire’s disease uses to reproduce inside the cells it infects....
  12. Patient-derived stem cells could improve drug research for Parkinson’s Researchers have taken a step toward personalized medicine for Parkinson’s disease, by investigating signs of the disease in patient-derived cells and testing how the cells respond to drug treatments. The study was funded by the National Institutes of Health....
  13. Medicare, Alzheimer’s Disease Neuroimaging Initiative enters next phase of research The National Institutes of Health is expanding the Alzheimer’s Disease Neuroimaging Initiative (ADNI), a groundbreaking study that will recruit hundreds of new volunteers to help define the subtle changes that may take place in the brains of older people many years before overt symptoms of Alzheimer’s disease appear. ADNI is the largest public-private partnership to […]...
  14. Arsenic turns stem cells cancerous, spurring tumor growth Researchers at the National Institutes of Health have discovered how exposure to arsenic can turn normal stem cells into cancer stem cells and spur tumor growth. Inorganic arsenic, which affects the drinking water of millions of people worldwide, has been previously shown to be a human carcinogen. A growing body of evidence suggests that cancer […]...
  15. Medicare Card, Genetic mystery of Behcet’s disease unfolds along the ancient Silk Road Medicare Card, Genetic mystery of Behcet's disease unfolds along the ancient Silk Road...